The metabolism of sulphonamides

The metabolism of sulphonamides.

p-Aminomethylbenzenesulphonamide (I) was first described by Miller, Sprague, Kissinger & McBurney (1940), and is used in therapy as its hydrochloride, Ambamide (formerly Marfanil). Its antibacterial properties were studied by Klartr (1941) who found it to be less active than sulphanilamide against streptococci, but more active against anaerobic bacteria (cf. Schoop & Stoltz, 1941 Hamre, Walker,...

The metabolism of four sulphonamides in cows.

1. The metabolism of sulphanilamide, sulphadimidine (4,6-dimethyl-2-sulphanilamidopyrimidine), sulphamethoxazole (5-methyl-3-sulphanilamidoisoxazole) and sulphadoxine (5,6-dimethoxy-4-sulphanilamidopyrimidine) given by intravenous injection has been examined in cows. 2. The sulphonamides were present mainly as unchanged drugs in blood samples collected 2h after administration. 3. The sulphonami...

The Sulphonamides in Bacillary Dysentery

Sulphonamides: A Pharmaceutical Review

Sulphonamides are the first effective chemotherapeutic agents used for bacterial infection in humans. Sulfonamides have a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, anti retroviral, anti cancer, antiinflammatory, and used as diuretic. This review consists of a discussion on the...

Sulphonamides in Undulant Fever